NCCR-Synapsy

The Synaptic Bases of Mental Diseases

The Harmful Effects of Stress Unraveled – Alexandre Dayer

The 12th Synapsy newsletter is rich with interviews and portraits of students, clinical scientists and more senior researchers from the developmental stress working group of Synapsy (work package 4, WP#4). Its objective is to evaluate the long-term effect of exposure Read more…


Anti-stress meditation

Is meditation effective as an early intervention to reduce reactivity to stress and anxiety? The Mindfulteen study investigates the question using brain imaging. Mindfulness meditation is a technique borrowed from oriental medicine that consists of training oneself to be in Read more…


Breaking the transmission of trauma

Children of mothers with post-traumatic stress disorder have difficulty processing their emotions. Defining the neural bases of this dysfunction will help develop future treatments. Transmitting information, you do not have is by its very nature a tricky, even impossible, exercise. Read more…


No clinical work without understanding the basics

Silvia Monari explains the difficult choice she had to make between medicine and life sciences when deciding on what direction her studies would take. Silvia tells us how she intends to detect biomarkers of disease and possible therapeutic intervention for Read more…


Mapping the emotional management of trauma

Trauma can induce fear pathologies, which are treated using psychotherapeutic approaches whose brain pathways have recently been identified. Fear leaves traces in the brain, and remembering it causes a feeling of discomfort. During extreme trauma—such as the shock of war, Read more…


Tracking neurogliaform cells and their role in the cortical microcircuit

Studying neurogliaform-type interneurons involves the five key elements of stress-related pathologies: brain development, the prefrontal cortex, serotonergic pathway, interneurons and plasticity. Here’s how.   Experience constantly alters the activity of the brain and the structure of the neural networks. Known Read more…


Maternal exposure to violence and child psychopathology

Synapsy has been following the children of mothers suffering from post-traumatic stress disorder due to interpersonal violence since they were 12 months of age. They are now reaching maturity, just like research projects designed to understand and treat stress-related disorders. Read more…


PTSD: Daniel Schechter Published a New Study on Parental Reflective Functioning

Parental Reflective Functioning is a parent’s capacity to infer mental states in herself and her child. Parental Reflective Functioning is linked to the quality of parent-child attachment and promotes parent-child mutual emotion regulation. The group of Daniel Schechter, Medical Director Read more…