AXIS 2 : ENVIRONMENT AND THE BRAIN
AXIS-2 ENVIRONMENTAL FACTORS
Psychopathological consequences of stress during development and from traumatic life experiences.
WP#4 – DEVELOPMENTAL STRESS
WP#5 – MODD DISORDERS
WP#4 - DEVELOPMENTAL STRESS
The objective of this project is to evaluate, both in humans and in mice, the long-term effect of exposure to stress at different developmental stages . A major focus will be the role of the HPA axis as well as that of glucocorticoids, which will be analyzed longitudinally.Physiological, behavioral and epigenetic markers will also be studied. The role of serotonin will be further investigated with regards to genetic and epigenetic alterations associated with perinatal stress as well as during the development of cortical neurons.
Clinical Cohorts – Principal Investigator
Daniel Schechter
Fundamental Neurosciences – Principal Investigators
Alexandre Dayer
Johannes Gräff
Anthony Holtmaat
Andreas Lüthi
Carmen Sandi
WP#5 - MOOD DISORDERS
The objective of this project is to evaluate, both in humans and in mice, the long-term effect of exposure to stress at different developmental stages . A major focus will be the role of the HPA axis as well as that of glucocorticoids, which will be analyzed longitudinally.Physiological, behavioral and epigenetic markers will also be studied. The role of serotonin will be further investigated with regards to genetic and epigenetic alterations associated with perinatal stress as well as during the development of cortical neurons.
Clinical Cohorts – Principal Investigators
Jean-Michel Aubry
Martin Preisig
Pierre Marquet
Fundamental Neurosciences – Principal Investigators
Pierre Magistretti
