NCCR-Synapsy

The Synaptic Bases of Mental Diseases

AXIS 2 : ENVIRONMENT AND THE BRAIN

AXIS-2 ENVIRONMENTAL FACTORS

Psychopathological consequences of stress during development and from traumatic life experiences.

WP#4 – DEVELOPMENTAL STRESS

WP#5 – MODD DISORDERS

WP#4 - DEVELOPMENTAL STRESS

The objective of this project is to evaluate, both in humans and in mice, the long-term effect of exposure to stress at different developmental stages . A major focus will be the role of the HPA axis as well as that of glucocorticoids, which will be analyzed longitudinally.Physiological, behavioral and epigenetic markers will also be studied. The role of serotonin will be further investigated with regards to genetic and epigenetic alterations associated with perinatal stress as well as during the development of cortical neurons.

Clinical Cohorts – Principal Investigator

Daniel Schechter portrait

Daniel Schechter

CLINICAL COHORTS

UNIGE & HUG-SPEA

Research lab >

and

NYU Langone Health (profile) >

UNIGE
Dept of Basic Neurosciences
CMU
Rue Michel Servet 1
CH-1205 Geneva

E-Mail

and

NYU Langone Health
Child Study Center
1 Park Avenue, 7th Floor
New York, NY 10016
+1 646-754-5000

E-Mail

 

Fundamental Neurosciences – Principal Investigators

Alexandre Dayer 2019

Alexandre Dayer

ANIMAL MODELS

UNIGE

EPFL

UNIL

CHUV

Research Lab >

University of Geneva
Department of Basic Neurosciences
Centre Médical Universitaire (CMU)
Rue Michel-Servet 1
CH-1211 Geneva

E-Mail 
+41 22 379 53 86

Joannes Gräff portrait

Johannes Gräff

ANIMAL MODELS

EPFL Sciences de la Vie
BMI-UPGRAEFF
Station 19
CH-1015 Lausanne

E-Mail
+41 21 693 07 13

Anthony Holtmaat portrait

Anthony Holtmaat

ANIMAL MODELS

University of Geneva
Department of Basic Neurosciences
Centre Médical Universitaire (CMU)
Rue Michel-Servet 1
CH-1211 Geneva

E-Mail
+41 22 379 54 28

Carmen Sandi portrait

Carmen Sandi

ANIMAL MODELS

EPFL – Sciences de la Vie
Brain Mind Institute (BMI)
Laboratory of Behavioral Genetics (LGC)
SV 2805 – Station 19
CH-1015 Lausanne

E-Mail
+41 21 693 95 34

Ralf Schneggenburger portrait

Ralf Schneggenburger

ANIMAL MODELS

Laboratory of Synaptic Mechanism (LSYM)
EPFL Sciences de la Vie
BMI-LSYM
Station 19
CH-1015 Lausanne

E-Mail
+41 21 693 53 64

WP#5 - MOOD DISORDERS

The aim of this project is to identify biological markers early in the course of bipolar disorders in high-risk children. The means used for this is brain imaging, and investigation of the HPA axis, of possible immune and epigenetic alterations as well as of growth factors. Within the realm of these conditions, the role of astrocytes are also investigated at the cellular and molecular level and in the response to antidepressants.

Clinical Cohorts – Principal Investigators

Jean-Michel Aubry portrait

Jean-Michel Aubry

CLINICAL COHORTS

HUG
Psychiatric Specialties
Rue de Lausanne 20 bis
CH-1201 Geneva

E-Mail
+41 22 305 45 11

Pierre Marquet portrait

Pierre Marquet

CLINICAL COHORTS

CHUV, Dept Psychiatry – Imagerie >

and

LAVAL University (Québec) LRNP >

CHUV
Unité de recherche imagerie et plasticité
Site de Cery
1008 Prilly-Lausanne

E-Mail
+41 21 314 48 73

Martin Preisig portrait

Martin Preisig

CLINICAL COHORTS

CHUV – Centre for Psychiatric Epidemiology and Psychopathology (CEPP) >

CHUV
Centre d’épidémiologie psychiatrique et de psychopathologie
Site de Cery
CH-1008 Prilly-Lausanne

E-Mail
Tel. +41 21 314 3552

Fundamental Neurosciences – Principal Investigator

Pierre Magistretti portrait

Pierre Magistretti

ANIMAL MODELS

UNIL CNP

Centre de neurosciences psychiatriques
Site de Cery
Route du Mont
1008 Prilly
Switerzland

E-Mail
+41 21 643 69 49