AXIS 2 : ENVIRONMENT AND THE BRAIN

AXIS-2 ENVIRONMENTAL FACTORS

Psychopathological consequences of stress during development and from traumatic life experiences.

WP#4 – DEVELOPMENTAL STRESS

WP#5 – MODD DISORDERS

WP#4 - DEVELOPMENTAL STRESS

The objective of this project is to evaluate, both in humans and in mice, the long-term effect of exposure to stress at different developmental stages . A major focus will be the role of the HPA axis as well as that of glucocorticoids, which will be analyzed longitudinally.Physiological, behavioral and epigenetic markers will also be studied. The role of serotonin will be further investigated with regards to genetic and epigenetic alterations associated with perinatal stress as well as during the development of cortical neurons.

Clinical Cohorts – Principal Investigator

Daniel Schechter portrait

Daniel Schechter

Fundamental Neurosciences – Principal Investigators

Alexandre Dayer portrait

Alexandre Dayer

Joannes Gräff portrait

Johannes Gräff

Anthony Holtmaat portrait

Anthony Holtmaat

Andreas Lüthi portrait

Andreas Lüthi

Carmen Sandi portrait

Carmen Sandi

WP#5 - MOOD DISORDERS

The objective of this project is to evaluate, both in humans and in mice, the long-term effect of exposure to stress at different developmental stages . A major focus will be the role of the HPA axis as well as that of glucocorticoids, which will be analyzed longitudinally.Physiological, behavioral and epigenetic markers will also be studied. The role of serotonin will be further investigated with regards to genetic and epigenetic alterations associated with perinatal stress as well as during the development of cortical neurons.

Clinical Cohorts – Principal Investigators

Jean-Michel Aubry portrait

Jean-Michel Aubry

Martin Preisig portrait

Martin Preisig

Pierre Marquet portrait

Pierre Marquet

Fundamental Neurosciences – Principal Investigators

Pierre Magistretti portrait

Pierre Magistretti

Andrea Volterra portrait

Andrea Volterra