Psychopathological consequences of stress during development and from traumatic life experiences.
WP#4 – DEVELOPMENTAL STRESS
The objective of this project is to evaluate, both in humans and in mice, the long-term effect of exposure to stress at different developmental stages . A major focus will be the role of the HPA axis as well as that of glucocorticoids, which will be analyzed longitudinally.Physiological, behavioral and epigenetic markers will also be studied. The role of serotonin will be further investigated with regards to genetic and epigenetic alterations associated with perinatal stress as well as during the development of cortical neurons.
PROJECT LEADERS
- Clinical cohorts
François ANSERMET
Daniel SCHECHTER
- Fundamental neurosciences
Alexandre DAYER
Johannes GRAEFF
Anthony HOLTMAAT
Carmen SANDI
WP#5 – MOOD DISORDERS
The aim of this project is to identify biological markers early in the course of bipolar disorders in high-risk children. The means used for this will be brain imaging, and investigation of the HPA axis, of possible immune and epigenetic alterations as well as of growth factors. Within the realm of these conditions, the role of astrocytes will also investigated at the cellular and molecular level and in the response to antidepressants.
PROJECT LEADERS
- Clinical cohorts
Jean-Michel AUBRY
Alexandre DAYER
Pierre MARQUET
Martin PREISIG
- Fundamental neurosciences
Paola BEZZI
Christian LUESCHER
Andreas LUETHI
Pierre MAGISTRETTI
Andrea VOLTERRA