NCCR-Synapsy

The Synaptic Bases of Mental Diseases

Same signature for several mental illnesses

A team from NCCR-Synapsy has identified a common neurobiological signature of dysfunction in the brain circuits involved in regulating emotions in three clinically-distinct psychiatric illnesses. People suffering from attention-deficit hyperactivity disorder (ADHD), bipolar disorder or borderline personality disorder share a Read more…


Lactate reveals all about its antidepressant prowess

Neuroscientists at Synapsy have identified one of the mechanisms behind the antidepressant effect of lactate, a molecule produced by the body during exercise. Its key features – lactate, NADH and neurogenesis – will pave the way for new treatment possibilities. Read more…


Why making the right choice is difficult when you’re stressed

Study by members of Synapsy, the Swiss National Centre of Competence in Research in psychiatric disorders, explains why we make poor decisions after stress even when motivated by the prospect of reward. The ability to assess the costs and benefits Read more…


Has the ideal target for treating anxiety been discovered?

Synapsy’s neuroscientists based at EPFL have identified a cell molecule that can regulate anxiety and prevent depression. Located at the crossroads of multiple cellular mechanisms, this molecule reconciles the great heterogeneity of scientific observations and paves the way for future Read more…


From academia to entrepreneurship – seizing an opportunity to make a significant contribution to the treatment of neurological disorders

We spoke with Charles Finsterwald, PhD, Chief Scientific Officer and co-founder of the start-up Gliapharm about his career path and his decision to switch from fundamental research to application. An interest in neuroscience After a bachelor in biology and a Read more…


Lactate, a prospect for the treatment of depression

According to WHO, more than 264 million people in the world suffer from depression, a disorder that has a major impact on all facets of the lives of those it affects. It became the first cause of invalidity in 2020. Read more…


Holography and cellular reprogramming in the quest for biomarkers

Bipolar disorders affect some 2% of the population. Patients present a wide variety of clinical symptoms of which many can be especially handicapping. A new approach to find biomarkers, driven by Pascal Jourdain, could change the game by improving treatment Read more…


A career at the intersection of physics and psychiatry

Pierre Marquet’s career path has been rather untypical. Combining qualifications in physics and psychiatry-psychotherapy, he is a clinical researcher “par excellence”, engaged for over 20 years in the development of knowledge about the biological dimensions of mental disorders. His career Read more…


From science to yoga — and back to science

After initial studies in science, Zeynep Knight-Celen opts for a life practicing and teaching yoga. Ten years later her interest in the workings of the mind rekindles her scientific curiosity and leads her to a PhD position in the Mindfulness Read more…