NCCR-Synapsy

The Synaptic Bases of Mental Diseases

Joint NCCR Synapsy – IRCN “22q” Workshop, Jul y 6-7, 2019, Tokyo, Japan

This past weekend, a joint NCCR Synapsy-IRCN workshop took place University of Tokyo. Several Synapsy PIs from UNIGE attended and presented their research (Profs. Alexandre Dayer, Stephan Eliez, Marie Schaer, Camila Bellone, Alan Carleton). Copy number variations in chromosome 22q Read more…


Back to the sources of neural diversity

jabaudon_progen

By deciphering the genetic programs of neurons of the cerebral cortex, Swiss and Belgian researchers unravel the mechanisms controlling the genesis of cells in one of the most essential parts of our brain. The cortex is a complex brain region Read more…


Impulsivity increases with severity of childhood trauma in bipolar disorder

impulsivity

In the context of the WP#5, the clinical dimension of impulsivity was studied in people with attention deficit disorder either with or without hyperactivity (ADHD), borderline personality disorder (BPD) or bipolar disorder (BD). This study showed a high level of Read more…


Phase-3 : Synapsy ranked at the top by the SNSF

networking

Entering Phase-3 has been achieved following a long preparatory and competitive process involving coordinated work from NCCR members at all levels. At the end of January 2019, the Synapsy management team received from the Swiss National Science Foundation (SNSF) the Read more…


The fascinating quest for neuronal origins

neuron

Confocal microscopy image showing the embryonic preoptic region, sitting on the brain floor. Cortical neurogliaform cells come from this region that borders the third ventricle (middle, in black), marked by the expression of the transcription factor HMX3 (in red). Researchers Read more…


Unraveling the biological function of a 22q11 locus gene

Aude Chenu-Molinard

Synapsy researchers reveal the developmental function of a new schizophrenia (SZ) risk-gene. The candidate SZ-risk gene DGCR2 is located in the 22q11.2 locus, whose deletion is a major risk factor for SZ. In a recent paper published in Biological Psychiatry, Aude Molinard-Chenu, former MD-PhD Read more…


Deciphering the emergence of neuronal diversity

Inhibitory interneurons labelled with a fluorescent molecule (in green) are distributed in the cerebral cortex. These cells were individually isolated and single cell transcriptomics revealed markers (in white) specifically expressed in distinct sub-groups of interneurons. The development of cerebral cortex Read more…


Impaired regulation of serotonin affects positioning of brain cells

Serotonin cells

In a study of infant mice, researchers have found that the positioning of brain cells is affected by early-life impairment of the system that regulates serotonin — a key brain chemical targeted by antidepressants and known to regulate mood. Like Read more…


A new role for serotonin in psychiatric vulnerability

serotonin

Prof Dayer’s team has unveiled the crucial role of a serotonin receptor in the assembly of brain circuits. Serotonin, a neurotransmitter in our brain, is at the root of our moods. Research has shown that poor regulation of the serotonin Read more…