The fascinating quest for neuronal origins

neuron

Confocal microscopy image showing the embryonic preoptic region, sitting on the brain floor. Cortical neurogliaform cells come from this region that borders the third ventricle (middle, in black), marked by the expression of the transcription factor HMX3 (in red). Researchers Read more…


Unraveling the biological function of a 22q11 locus gene

Aude Chenu-Molinard

Synapsy researchers reveal the developmental function of a new schizophrenia (SZ) risk-gene. The candidate SZ-risk gene DGCR2 is located in the 22q11.2 locus, whose deletion is a major risk factor for SZ. In a recent paper published in Biological Psychiatry, Aude Molinard-Chenu, former MD-PhD Read more…


Deciphering the emergence of neuronal diversity

Inhibitory interneurons labelled with a fluorescent molecule (in green) are distributed in the cerebral cortex. These cells were individually isolated and single cell transcriptomics revealed markers (in white) specifically expressed in distinct sub-groups of interneurons. The development of cerebral cortex Read more…


Impaired regulation of serotonin affects positioning of brain cells

Serotonin cells

In a study of infant mice, researchers have found that the positioning of brain cells is affected by early-life impairment of the system that regulates serotonin — a key brain chemical targeted by antidepressants and known to regulate mood. Like Read more…


A new role for serotonin in psychiatric vulnerability

serotonin

Prof Dayer’s team has unveiled the crucial role of a serotonin receptor in the assembly of brain circuits. Serotonin, a neurotransmitter in our brain, is at the root of our moods. Research has shown that poor regulation of the serotonin Read more…