NCCR-Synapsy

The Synaptic Bases of Mental Diseases

The Harmful Effects of Stress Unraveled – Alexandre Dayer

The 12th Synapsy newsletter is rich with interviews and portraits of students, clinical scientists and more senior researchers from the developmental stress working group of Synapsy (work package 4, WP#4). Its objective is to evaluate the long-term effect of exposure Read more…


Halfway between cell biology and patient care

Zoé Schilliger was one of the three 2019 winners of the Synapsy clinician-researcher grant. She is embarking on a PhD on anxiety that is based on the expertise of two Synapsy work packages. It is a fascinating project that combines Read more…


Making a living on two wheels and electroencephalography

Virginie Perizzolo tells us how cycling and speech therapy helped her recently graduate from the Lemanic Neuroscience Doctoral School.   What training did you do to become a doctor in neuroscience? First, I got a bachelor’s degree in speech therapy Read more…


Tracking neurogliaform cells and their role in the cortical microcircuit

Studying neurogliaform-type interneurons involves the five key elements of stress-related pathologies: brain development, the prefrontal cortex, serotonergic pathway, interneurons and plasticity. Here’s how.   Experience constantly alters the activity of the brain and the structure of the neural networks. Known Read more…


Neural signature of trait anxiety

The neurological basis of trait anxiety, a risk factor for the development of neuropsychiatric diseases, revealed by Synapsy researchers. Trait anxiety is a personality dimension related to the extent to which events are perceived as potentially threatening. The identification of Read more…


Anxiety: Brain Mitochondria as a Treatment Target

Carmen Sandi, professor at EPFL’s Brain Mind Institute and co-director of the NCCR-Synapsy, published a review on the connection between anxiety and brain mitochondriain the Journal Trends in Neurosciences with her colleague Michaela Filiou from the Max Planck Institute.They highlight Read more…


Identification of a behavioral and neural signature of trait anxiety related to differences in effortful motivated behavior

The combined expertise of Carmen Sandi and Christoph Michel’s labs allowed to better understand the neurological basis of trait anxiety, a risk factor for the development of neuropsychiatric diseases. Trait anxiety is a personality dimension related to the extent to Read more…


Making mental health a global priority

Who hasn’t felt a sense of loss or detachment from our families, friends, and regular routines, or experienced nervousness and anxiety about changes in our personal and professional lives? For some, fear and worry constantly distract, confuse, and agitate. For Read more…


Hierarchy in animals: Anxiety can kill your social status

Anxiety cells

Mitochondria in the neurons of the nucleus accumbens. Neuroscientists at EPFL identify a brain region that links anxious temperament to low social status. The researchers were able to tweak social hierarchy in animals by using vitamin B3. There are important Read more…