NCCR-Synapsy

The Synaptic Bases of Mental Diseases

The Harmful Effects of Stress Unraveled – Alexandre Dayer

The 12th Synapsy newsletter is rich with interviews and portraits of students, clinical scientists and more senior researchers from the developmental stress working group of Synapsy (work package 4, WP#4). Its objective is to evaluate the long-term effect of exposure Read more…


Breaking the transmission of trauma

Children of mothers with post-traumatic stress disorder have difficulty processing their emotions. Defining the neural bases of this dysfunction will help develop future treatments. Transmitting information, you do not have is by its very nature a tricky, even impossible, exercise. Read more…


Tracking neurogliaform cells and their role in the cortical microcircuit

Studying neurogliaform-type interneurons involves the five key elements of stress-related pathologies: brain development, the prefrontal cortex, serotonergic pathway, interneurons and plasticity. Here’s how.   Experience constantly alters the activity of the brain and the structure of the neural networks. Known Read more…


Neural signature of trait anxiety

The neurological basis of trait anxiety, a risk factor for the development of neuropsychiatric diseases, revealed by Synapsy researchers. Trait anxiety is a personality dimension related to the extent to which events are perceived as potentially threatening. The identification of Read more…


Identification of a behavioral and neural signature of trait anxiety related to differences in effortful motivated behavior

The combined expertise of Carmen Sandi and Christoph Michel’s labs allowed to better understand the neurological basis of trait anxiety, a risk factor for the development of neuropsychiatric diseases. Trait anxiety is a personality dimension related to the extent to Read more…