NCCR-Synapsy

The Synaptic Bases of Mental Diseases

Drugs of abuse: Identifying the addiction circuit

mouse brain

Section of a mouse brain showing in red the circuit that reinforces the behaviour, in green the circuit that reinforces the decision to continue. If the green projection is very active, the mice self-stimulate their red projection despite negative consequences. Read more…


Dopamine, a key component of heroin addiction

Lüscher_nov2018.jpeg

Photo illustrating dopaminergic neurons (in red). In green, are dopaminergic neurons that have been activated by heroin. In blue, a marking of the nuclei of the cells. © UNIGE Addiction refers to the repeated and irrepressible desire to do or Read more…


iTango: A switch to illuminate the neurons

ligthing neuron

The blue light activates the iTango system. Mouse implanted with an optical fiber that directs light to the parts of the brain involved in the addictive behavior. Swiss and American researchers are developing a technique of unprecedented precision to visualize Read more…


Theodore Ott prize 2017 to Christian Lüscher and Andrea Volterra

Andrea Volterra & Christian Lüscher The Theodore Ott Award 2017 will be granted to two researchers for their remarkable works in neurosciences : Prof. Andrea Volterra from the Lausanne university. His group explores the central role, long ignored, of astrocytes Read more…


2016 Koetser Award to Christian Lüscher

Christian Lüscher Koetser prize 2016

The Betty and David Koetser Foundation for research on the brain rewards this year Christian Lüscher, Professor at the Department of fundamental neurosciences of the Faculty of Medicine at UNIGE (his group web page). Professor Lüscher, a specialist of neural Read more…


SHANK3 controls maturation of social reward circuits in the VTA

shShank3 Imagery

The autism spectrum disorders are a heterogeneous group of neurodevelopmental disorders whose main characteristic alterations in social communication, restricted interests and repetitive behaviors. If the assumptions to identify alterations in brain circuits that could be responsible for autism disorders are Read more…


Christian Lüscher becomes a member of the SAMS

Christian Lüscher portrait

Professor Christian Lüscher from the University of Geneva (UNIGE) and a NCCR Synapsy member joins the Swiss Academy of Medical Sciences (SAMS) The senate of the Swiss Academy of Medical Sciences has appointed Professor Lüscher as individual member of the Read more…


Adapting optogenetics to reverse cocaine behavior

optogenetics

Borrowing ideas from optogenetics, which uses light to control neurons, Christian Lüscher and colleagues have developed a combination therapy to treat cocaine-induced behaviors in mice. Recent research has shown that it may be possible to use optogenetics to reverse cocaine-related Read more…


Cocaine tampers with the brain’s brakes

cocaine leaves

New results from Christian Lüscher and his group show that cocaine not only acts on excitatory transmission but also affects inhibitory transmission provoking loss of an intrinsic brake in the brain. Cocaine-evoked synaptic plasticity in the nucleus accumbens and the Read more…