The Synaptic Bases of Mental Diseases

The insular cortex processes pain and drives learning from pain


Neurons and their synapses in the mouse brain.  © Aiste Baleisyte, EPFL Neuroscientists at EPFL have discovered an area of the brain, the insular cortex, that processes painful experiences and thereby drives learning from aversive events. Acute pain, e.g. hitting Read more…

Interneuron plasticity initiates the rewiring of the auditory cortex

interneurons plasticity

 EPFL neuroscientists have found that the output synapses of certain interneurons in the cortex show long-term plasticity. This plasticity occurs during a critical period of brain development and might contribute to the experience-dependent rewiring of brain circuits. Interneurons inhibit the Read more…

Nobel Prize 2013 : Thomas Südhof, a pioneer of synaptic mechanisms

thomas sudhof portrait

Thomas Südhof Ralf Schneggenburger shares his views on the 2013 Nobel Prize in Physiology or Medicine laureate. The 2013 Nobel Prize honours three scientists who have solved the mystery of how the cell organizes its transport system, and how vesicles Read more…

Scientists discover the origin of a giant synapse

calyx of held synapse

Calyx of Held synapse covering the neuron soma How do we locate the spatial position of sounds? Scientists have revealed a mechanism responsible for the creation of giant synapses in the brain that allow us to efficiently process auditory information. Read more…