NCCR-Synapsy

The Synaptic Bases of Mental Diseases

A new role for serotonin in psychiatric vulnerability

serotonin

Prof Dayer’s team has unveiled the crucial role of a serotonin receptor in the assembly of brain circuits. Serotonin, a neurotransmitter in our brain, is at the root of our moods. Research has shown that poor regulation of the serotonin Read more…


How chronic stress tears us apart

stress-apart

Chronic stress can lead to behavioral problems. Prof Carmen Sandi’s team has discovered an important synaptic mechanism: the activation of a cleaving enzyme, leading to these problems. Why is it that when people are too stressed they are often grouchy, Read more…


Long-term potentiation in silent neurons

silent neurons

The team led by Anthony Holtmaat, professor at UNIGE and member of the NCCR-Synapsy, was able to demonstrate that the sensory stimulus alone can generate long-term synaptic. Their research on this memory of silent neurons is published in Nature. When Read more…


An innovative way to reduce traumatic memories

old photos illustration

In a recent meta-analysis, Johannes Gräff (lab), project leader at NCCR-Synapsy and at the Brain Mind Institute (EPFL) and Li-Huei Tsai from the MIT review the existing literature about long-term traumatic memories. They find that these memories are extremely resistant Read more…


Carmen Sandi awarded the Behavioral Brain Research Prize

carmen sandi at the FENS

Carmen Sandi, project leader on the “Developmental stress” project of Synapsy and head of the Brain Mind Institute (EPFL), received the Behavioral Brain Research Prize last Sunday. On the occasion of the biannual Forum 2014 of the FENS-Federation of the Read more…


Childhood trauma leaves marks on the brain

sad adolescent

EPFL scientists have found that childhood trauma leaves a lasting imprint on the brain – a structural change that is related to a predisposition to violence. It is well known that violent individuals are often themselves the victims of psychological Read more…