The Synaptic Bases of Mental Diseases


Scientific publications from members of the Synapsy community in peer-reviewed journals.

*Equal contribution in each publication, accordingly.

Khelfaoui M, Gambino F, Houbaert X, Ragazzon B, Müller C, Carta M, Lanore F, Srikumar BN, Gastrein P, Lepleux M, Zhang CL, Kneib M, Poulain B, Reibel-Foisset S, Vitale N, Chelly J, Billuart P, Lüthi A, Humeau Y;
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway.
Philosophical Transactions of the Royal Society of London, Biological Sciences 369(1633):20130160, Dec 2013. doi:10.1098/rstb.2013.0160 >

Badoud D, Billieux J, van der Linden M, Eliez S, Debbané M;
Encoding style and its relationships with schizotypal traits and impulsivity during adolescence.
Psychiatry Research 210(3):1020-1025, Dec 2013. doi:10.1016/j.psychres.2013.08.044 >

Donato F, Rompani SB, Caroni P;
Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning.
Nature 504(7479):272-276, Dec 2013. doi:10.1038/nature12866 >

Draganski B, Lutti A, Kherif F;
Impact of brain aging and neurodegeneration on cognition: evidence from MRI.
Current Opinion in Neurology 26(6):640-645, Dec 2013. doi:10.1097/WCO.0000000000000029 >

Adaszewski S, Dukart J, Kherif F, Frackowiak R, Draganski B, Alzheimer’s Disease Neuroimaging Initiative.
How early can we predict Alzheimer’s disease using computational anatomy?
Neurobiology of Aging 34(12):2814-2826, Dec 2013. doi:10.1016/j.neurobiolaging.2013.06.015 >

Ortuño-Sierra J, Badoud D, Knecht F, Paino M, Eliez S, Fonseca-Pedrero E, Debbané M;
Testing measurement invariance of the schizotypal personality questionnaire-brief scores across Spanish and Swiss adolescents.
PLoS One 8(12):e82041, Dec 2013. doi:10.1371/journal.pone.0082041 >

Habersaat S, Borghinia A, Faure N, Nessi J, Forcada-Guex M, Pierrehumbert B, Ansermet F, Müller-Nix C;
Emotional and neuroendocrine regulation in very preterm and full-term infants at 6 months of age.
European Journal of Developmental Psychology 10(6):691-706, May 2013. doi:10.1080/17405629.2013.787924 >

Habersaat S, Monnier M, Peter C, Bolomey L, Borghini A, Despars J, Pierrehumber B, Müller-Nix C, Ansermet F, Hohlfeld J;
Early mother-child interaction and later quality of attachment in infants with an orofacial cleft vompared to infants without cleft.
The Cleft Palate-Craniofacial Journal 50(6):704-712, Nov 2013. doi:10.1597/12-094.1 >

Herrmann CS, Murray MM;
Seeing things that are not there: illusions reveal how our brain constructs what we see.
Frontiers for Young Minds, Nov 2013, doi:10.3389/frym.2013.00006 >

Cordero I, Ansermet F, Sandi C;
Long-term programming of enhanced aggression by peripuberty stress in female rats.
Psychoneuroendocrinology 38(11):2578-2569, Nov 2013. doi:10.1016/j.psyneuen.2013.07.005 >

Kohl C, Riccio O, Grosse J, Zanoletti O, Fournier C, Klampfl SM, Schmidt MV, Sandi C.
The interplay of conditional NCAM-knockout and chronic unpredictable stress leads to increased aggression in mice.
Stress 16(6):647-654, Nov 2013. doi:10.3109/10253890.2013.840824 >

Lüscher C;
Drug-evoked synaptic plasticity causing addictive behavior.
Journal of Neuroscience 33(45):17641-17646, Nov 2013. doi:10.1523/JNEUROSCI.3406-13.2013 >

Mutlu AK, Schneider M, Debbané M, Badoud D, Eliez S, Schaer M;
Sex differences in thickness, and folding developments throughout the cortex.
Neuroimage 82:200-207, Nov 2013. doi:10.1016/j.neuroimage.2013.05.076 >

Sachidhanandam S, Sreenivasan V, Kyriakatos A, Kremer Y, Petersen CCH;
Membrane potential correlates of sensory perception in mouse barrel cortex.
Nature Neuroscience 16:1671-1677, Nov 2013. doi:10.1038/nn.3532 >

Sylwestrak E and Scheiffele P;
Neuroscience: Sculpting neuronal connectivity.
Nature 503(7474):42-43, Nov 2013. doi:10.1038/503042a >

Torrisi R;
Réponses neuroendocriniennes au stress chez les jeunes adultes nés grands prématurés : interaction entre le système HPA et le système ocytocinergique.
European Psychiatry 28(8S):15-16 art. S7B, Nov 2013. doi:org/10.1016/j.eurpsy.2013.09.037 >

Yuan T, Mameli M, O’ Connor EC, Dey PN, Verpelli C, Sala C, Perez-Otano I, Lüscher C, Bellone C;
Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors.
Neuron 80(4):1025-1038, Nov 2013. doi:10.1016/j.neuron.2013.07.050 >

Schaer M, Ottet M-C, Scariati E, Dukes D, Franchini M, Eliez S, Glaser B;
Decreased frontal gyrification correlates with altered connectivity in children with autism.
Frontiers in Human Neuroscience 7:750, Nov 2013. doi:10.3389/fnhum.2013.00750 >

Nikonenko I, Nikonenko A, Mendez P, Michurina TV, Enikolopov G, Muller D;
Nitric oxide mediates local activity-dependent excitatory synapse development.
Proceedings of the National Academy of Sciences 110(44):E4142-51, Oct 2013. doi:10.1073/pnas.1311927110 >

Griffa A, Baumann PS, Thiran JP, Hagmann P;
Structural connectomics in brain diseases.
NeuroImage 80:515-526, Oct 2013. >

Saxena S, Roselli F, Singh S, Leptien K, Julien JP, Gros-Louis F, Caroni P;
Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.
Neuron 80(1):80-96, Oct 2013. doi:10.1016/j.neuron.2013.07.027 >

Martin JL, Magistretti PJ, Allaman I;
Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes.
Current Drug Targets 14(11):1308-13021, Oct 2013. PMID: 23469874 >

Bakanidze G, Roinishvili M, Chkonia E, Kitzrow W, Richter S, Neumann K, Herzog MH, Brand A, Puls I;
Association of the nicotinic receptor ‘alpha’ 7 subunit gene (CHRNA7) with schizophrenia and visual backward masking.
Frontiers in Psychiatry 4:133, Oct 2013. doi:10.3389/fpsyt.2013.00133 >

Delattre V, La Mendola D, Meystre J, Markram H, Markram K;
Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.
Scientific Reports 3:2897, Oct 2013. doi:10.1038/srep02897 >

Choong E, Quteineh L, Cardinaux JR, Gholam-Rezaee M, Vandenberghe F, Dobrinas M, Bondolfi G, Etter M, Holzer L, Magistretti P, von Gunten A, Preisig M, Vollenweider P, Beckmann JS, Pralong FP, Waeber G, Kutalik Z, Conus P, Bochud M, Eap CB; ODEX team;
Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population.
JAMA Psychiatry 70(10):1011-1019, Oct 2013. doi:10.1001/jamapsychiatry.2013.187 >

Ottet MC, Schaer M, Debbané M, Cammoun L, Thiran JP, Eliez S;
Graph theory reveals dysconnected hubs in 22q11DS and altered nodal efficiency in patients with hallucinations.
Frontiers in Human Neuroscience 7:402, Sep 2013. doi:10.3389/fnhum.2013.00402 >

Moser DA, Aue T, Wang Z, Rusconi Serpa S, Favez N, Peterson BS, Schechter DS;
Limbic brain responses in mothers with post-traumatic stress disorder and comorbid dissociation to video clips of their children.
Stress 16(5):493-502, Sept 2013. doi:10.3109/10253890.2013.816280 >

Murray MM and Herrmann CS;
Illusory contours: a window onto the neurophysiology of constructing perception.
Trends in Cognitive Sciences 17(9):471-481, Sept 2013. doi:10.1016/j.tics.2013.07.004 >

Bocklisch C, Pascoli V, Wong JC, House DR, Yvon C, de Roo M, Tan KR, Lüscher C;
Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area.
Science 341(6153):1521-1525, Sept 2013. doi:10.1126/science.1237059 >

Pryce CR and Klaus F;
Translating the evidence for gene association with depression into mouse models of depression-relevant behaviour: current limitations and future potential.
Neuroscience & Biobehavioral Reviews 37(8):1380-402, Sept 2013. doi:10.1016/j.neubiorev.2013.05.003 >

Baumann PS, Crespi S, Marion-Veyron R, Solida A, Thonney J, Favrod J, Bonsack C, Do KQ, Conus P;
Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne): implementation of an early intervention programme for psychosis in Switzerland.
Early Intervention in Psychiatry 7(3):322-328, Aug 2013. doi:10.1111/eip.12037 >

Miguez M, Weber B, Debbané M, Balanzin D, Gex-Fabry M, Raiola F, Barbe RP, Vital Benhour M, Ansermet F, Eliez S, Aubry JM;
Screening for bipolar disorder in adolescents with the mood disorder questionnaire-adolescent version (MDQ-A) and the child bipolar questionnaire (CBQ).
Early Intervention in Psychiatry 7(3):270-277, Aug 2103.  doi:10.1111/j.1751-7893.2012.00388.x >

Creed MC, Lüscher C;
Drug-evoked synaptic plasticity: beyond metaplasticity.
Current Opinion in Neurobiology 23(4):553-558, Aug 2013. doi:10.1016/j.conb.2013.03.005 >

Ivankova K, Turecek R, Fritzius T, Seddik R, Prezeau L, Comps-Agrar L, Pin JP, Fakler B, Besseyrias V, Gassmann M, Bettler B;
Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12).
Journal Biological Chemistry 288(34):24848-24856, Aug 2013. doi:10.1074/jbc.M113.476770 >

Patterson MA, Lagier S, Carleton A;
Odor representations in the olfactory bulb evolve after the first breath and persist as an odor afterimage.
Proceedings of the National Academy of Sciences of the USA 110(35):E3340-49, Aug 2013. doi:10.1073/pnas.1303873110 >

Lambert C, Chowdhury R, Fitzgerald TH, Fleming SM, Lutti A, Hutton C, Draganski B, Frackowiak R, Ashburner J;
Characterizing aging in the human brainstem using quantitative multimodal MRI analysis.
Frontiers Human Neuroscience 7:462, Aug 2013. doi:10.3389/fnhum.2013.00462 >

Salomon R, Lim M, Pfeiffer C, Gassert R, Blanke O;
Full body illusion is associated with widespread skin temperature reduction.
Frontiers in behavioral neuroscience 7:65, Jul 2013. doi:10.3389/fnbeh.2013.00065 >

Dukart J, Mueller K, Villringer A, Kherif F, Draganski B, Frackowiak R, Schroeter ML, Alzheimer’s Disease Neuroimaging Initiative;
Relationship between imaging biomarkers, age, progression and symptom severity in Alzheimer’s disease.
Neuroimage Clinical 3:84-94, Jul 2013. doi:10.1016/j.nicl.2013.07.005 >

Dahoun T, Eliez S, Chen F, Badoud D, Schneider M, Larøi F, Debbané M.
Action simulation in hallucination-prone adolescents.
Frontiers in Human Neuroscience 7:329, Jul 2013. doi:10.3389/fnhum.2013.00329 >

Salomon R, Lim M, Kannape O, Llobera J, Blanke O;
“Self pop-out”: agency enhances self-recognition in visual search.
Experimental Brain Research 228(2):173-81, Jul 2013. doi:10.1007/s00221-013-3549-6 >

Xiao L, Michalski N, Kronander E, Gjoni E, Genoud C, Knott G, Schneggenburger R;
BMP signaling specifies the development of a large and fast CNS synapse.
Nature Neuroscience 16:856-64, May 2013. doi:10.1038/nn.3414 >

Vitalis T, Ansorge MS, Dayer AG;
Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT3A and 5-HT6 receptor subtypes.
Frontiers in Cellular Neuroscience 7:93, Jun 2013. doi:10.3389/fncel.2013.00093 >

Wentzel C, Sommer JE, Nair R, Stiefvater A, Sibarita JB, Scheiffele P;
mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.
Neuron 78(6):1012-1023, Jun 2013. doi:10.1016/j.neuron.2013.05.010 >

Debbané M, Badoud D, Balanzin D, Eliez S;
Broadly defined risk mental states during adolescence: disorganization mediates positive schizotypal expression.
Schizophrenia Research 147(1):153-156, Jun 2013. doi:10.1016/j.schres.2013.03.012 >

Michalski, N. Babai, N. Renier, DJ Perkel, A. Chédotal, R. Schneggenburger;
Robo3-driven axon midline crossing conditions functional maturation of a large commissural synapse.
Neuron 78(5):855-868, Jun 2013. doi:10.1016/j.neuron.2013.04.006 >

Salomon R, Lim M, Herbelin B, Hesselmann G, Blanke O;
Posing for awareness: Proprioception modulates access to visual consciousness in a continuous flash suppression task.
Journal of Vision 13(7):2, May 2013. doi:10.1167/13.7.2 >

Woodward SH, Kuo JR, Schaer M, Kaloupek DG, Eliez S.
Early adversity and combat exposure interact to influence anterior cingulate cortex volume in combat veterans.
Neuroimage Clinical 2:670-674, May 2013. doi:10.1016/j.nicl.2013.04.016 >

Herzog MH, Roinishvili M, Chkonia E, Brand A;
Schizophrenia and visual backward masking: a general deficit of target enhancement.
Frontiers in Psychology 4:254, May 2013. doi:10.3389/fpsyg.2013.00254 >

Poirier GL, Cordero MI, Sandi C;
Female vulnerability to the development of depression-like behavior in a rat model of intimate partner violence is related to anxious temperament, coping responses, and amygdala vasopressin receptor 1a expression.
Frontiers in Behavioral Neuroscience 7:35, May 2013. doi:10.3389/fnbeh.2013.00035 >

Schubert V, Lebrecht D, Holtmaat A;
Peripheral deafferentation-driven functional somatosensory map shifts are associated with local, not large-scale dendritic structural plasticity.
Journal of Neuroscience 33(22):9474-9487, May 213. doi:10.1523/JNEUROSCI.1032-13.2013 >

Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, Do KQ;
Perineuronal nets protect fast-spiking interneurons against oxidative stress.
Proceedings of the National Academy of Sciences of the USA 110(22):9130-9135, May 2013. doi:10.1073/pnas.1300454110 >

Rihs TA, Tomescu MI, Britz J, Rochas V, Custo A, Schneider M, Debbané M, Eliez S, Michel CM;
Altered auditory processing in frontal and left temporal cortex in 22q11.2 deletion syndrome: A group at high genetic risk for schizophrenia.
Psychiatry Research 212(2):141-149, May 2013. doi:10.1016/j.pscychresns.2012.09.002 >

Plomp G, Roinishvili M, Chkonia E, Kapanadze G, Kereselidze M, Brand A, Herzog MH;
Electrophysiological evidence for ventral stream deficits in schizophrenia patients.
Schizophrenia Bulletin 39(3):547-554, May 2013. doi:10.1093/schbul/sbr175 >

Dukart J, Kherif F, Mueller K, Adaszewski S, Schroeter ML, Frackowiak RS, Draganski B, Alzheimer’s Disease Neuroimaging Initiative;
Generative FDG-PET and MRI model of aging and disease progression in Alzheimer’s disease.
PLoS Computational Biology 9(4):e1002987, Apr 2013. doi:10.1371/journal.pcbi.1002987 >

Kulak A, Steullet P, Cabungcal JH, Werge T, Ingason A, Cuenod M, Do KQ;
Redox dysregulation in the pathophysiology of schizophrenia and bipolar disorder: Insights from animal models.
Antioxidants & Redox Signaling 18(12):1428-1443, Apr 2013. doi:10.1089/ars.2012.4858 >

Veenit V, Cordero MI, Tzanoulinou S, Sandi C;
Increased corticosterone in peripubertal rats leads to long-lasting alterations in social exploration and aggression.
Frontiers in Behavioral Neuroscience 7:26, Apr 2013. doi:10.3389/fnbeh.2013.00026 >

Cabungcal JH, Steullet P, Kraftsik R, Cuenod M, Do KQ;
Early-life insults impair parvalbumin interneurons via oxidative stress: Reversal by N-Acetylcysteine.
Biological Psychiatry 73(6):574-582, Mar 2013. doi:10.1016/j.biopsych.2012.09.020 >

Ottet MC, Schaer M, Cammoun L, Schneider M, Debbané M, Thiran JP, Eliez S;
Reduced fronto-temporal and limbic connectivity in the 22q11.2 deletion syndrome: vulnerability markers for developing schizophrenia?
PLoS One 8(3):e58429, Mar 2013. doi:10.1371/journal.pone.0058429 >

Fantin M, van der Kooij MA, Grosse J, Krummenacher C, Sandi C;
A key role for nectin-1 in the ventral hippocampus in contextual fear memory.
PLoS One 8(2):e56897, Feb 2013. doi:10.1371/journal.pone.0056897 >

Kohl C, Riccio O, Grosse J, Zanoletti O, Fournier C, Schmidt MV, Sandi C;
Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats.
PLoS One 8(2):e56871, Feb 2013. doi:10.1371/journal.pone.0056871 >

Maco B, Holtmaat A, Cantoni M, Kreshuk A, Straehle CN, Hamprecht FA, Knott GW;
Correlative in vivo 2 photon and focused ion beam scanning electron microscopy of cortical neurons.
PLoS One 8(2):e57405, Feb 2013. doi:10.1371/journal.pone.0057405 >

Papassotiropoulos A, Stefanova E, Vogler C, Gschwind L, Ackermann S, Spalek K, Rasch B, Heck A, Aerni A, Hanser E, Demougin P, Huynh KD, Luechinger R, Klarhöfer M, Novakovic I, Kostic V, Boesiger P, Scheffler K, de Quervain DJ;
A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene.
Molecular Psychiatry 18(2):255-263, Feb 2013. doi:10.1038/mp.2011.148 >

Marion-Veyron R, Mebdouhi N, Baumann PS, Thonney J, Crespi S, Conus P;
First episode psychosis and case management.
L’Évolution Psychiatrique 78(1):41-51, Jan 2013. >

Budreck EC, Kwon OB, Jung JH, Baudouin S, Thommen A, Kim HS, Fukazawa Y, Harada H, Tabuchi K, Shigemoto R, Scheiffele* P, Kim JH*;
Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling.
Proceedings of the National Academy of Sciences of the USA 110(2):725-730, Jan 2013. doi:10.1073/pnas.1214718110 >

Marquez C, Poirier GL, Cordero MI, Larsen MH, Groner A, Marquis J, Magistretti PJ, Trono D, Sandi C;
Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression.
Translational Psychiatry 3:e216, Jan 2013. doi:10.1038/tp.2012.144 >

Faure N, Habersaat S, Nessi J, Forcada-Guex M, Pierrehumbert B, Ansermet F, Muller-Nix C, Borghini A;
Validation d’une nouvelle grille de codage de la régulation émotionnelle avec le Laboratory Temperament Assessment Battery (Lab-TAB).
Devenir 25(1):27-48, Jan 2013. doi:10.3917/dev.131.0027 >