AXIS 2 : ENVIRONMENT AND THE BRAIN
AXIS-2 ENVIRONMENTAL FACTORS
Psychopathological consequences of stress during development and from traumatic life experiences.
WP#4 – DEVELOPMENTAL STRESS
WP#5 – MODD DISORDERS
WP#4 - DEVELOPMENTAL STRESS
The objective of this project is to evaluate, both in humans and in mice, the long-term effect of exposure to stress at different developmental stages . A major focus will be the role of the HPA axis as well as that of glucocorticoids, which will be analyzed longitudinally.Physiological, behavioral and epigenetic markers will also be studied. The role of serotonin will be further investigated with regards to genetic and epigenetic alterations associated with perinatal stress as well as during the development of cortical neurons.
Clinical Cohorts – Principal Investigator
Fundamental Neurosciences – Principal Investigators
Johannes Gräff
ANIMAL MODELS
EPFL-BMI
Publications (PubMed) >
EPFL Sciences de la Vie
BMI-UPGRAEFF
Station 19
CH-1015 Lausanne
E-Mail
+41 21 693 07 13
Anthony Holtmaat
ANIMAL MODELS
UNIGE-CMU
Publications (PubMed) >
University of Geneva
Department of Basic Neurosciences
Centre Médical Universitaire (CMU)
Rue Michel-Servet 1
CH-1211 Geneva
E-Mail
+41 22 379 54 28
Carmen Sandi
ANIMAL MODELS
Publications (PubMed) >
EPFL – Sciences de la Vie
Brain Mind Institute (BMI)
Laboratory of Behavioral Genetics (LGC)
SV 2805 – Station 19
CH-1015 Lausanne
E-Mail
+41 21 693 95 34
Ralf Schneggenburger
ANIMAL MODELS
Publications (PubMed) >
Laboratory of Synaptic Mechanism (LSYM)
EPFL Sciences de la Vie
BMI-LSYM
Station 19
CH-1015 Lausanne
E-Mail
+41 21 693 53 64
WP#5 - MOOD DISORDERS
The aim of this project is to identify biological markers early in the course of bipolar disorders in high-risk children. The means used for this is brain imaging, and investigation of the HPA axis, of possible immune and epigenetic alterations as well as of growth factors. Within the realm of these conditions, the role of astrocytes are also investigated at the cellular and molecular level and in the response to antidepressants.
Clinical Cohorts – Principal Investigators
Jean-Michel Aubry
CLINICAL COHORTS
Publications (PubMed) >
HUG
Psychiatric Specialties
Rue de Lausanne 20 bis
CH-1201 Geneva
E-Mail
+41 22 305 45 11
Pierre Marquet
CLINICAL COHORTS
Publications (PubMed) >
CHUV
Unité de recherche imagerie et plasticité
Site de Cery
1008 Prilly-Lausanne
E-Mail
+41 21 314 48 73
Martin Preisig
CLINICAL COHORTS
Publications (PubMed) >
CHUV
Centre d’épidémiologie psychiatrique et de psychopathologie
Site de Cery
CH-1008 Prilly-Lausanne
E-Mail
Tel. +41 21 314 3552
Fundamental Neurosciences – Principal Investigator
Pierre Magistretti
ANIMAL MODELS
Publications (PubMed) >
UNIL CNP
Centre de neurosciences psychiatriques
Site de Cery
Route du Mont
1008 Prilly
Switerzland
E-Mail
+41 21 643 69 49
